Journal article
Differences in the resting platelet proteome and platelet releasate between healthy children and adults
Charmaine Cini, Christina Yip, Chantal Attard, Vasiliki Karlaftis, Paul Monagle, Matthew Linden, Vera Ignjatovic
JOURNAL OF PROTEOMICS | ELSEVIER | Published : 2015
Abstract
UNLABELLED: Major age-related diseases such as cardiovascular disease and cancer are the primary causes of morbidity and mortality in Australia and worldwide. In our recent study characterising differences in the plasma proteome between healthy children and adults, a large number of proteins differentially expressed with age were found to be of platelet origin. This study aimed to characterise differences in the resting platelet proteome and the platelet releasate of healthy children compared to healthy adults. This study represents the setup of a procedure for the proteomic analysis of platelets from children. Differentially expressed platelet proteins were identified using Two-dimensional ..
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Funding Acknowledgements
The authors would like to thank the Anaesthetic and Surgical departments of the Royal Children's Hospital, Melbourne for facilitating the sample collection; X and Y from the Mass Spectrometry Facility at Bio21, and The University of Melbourne for their technical assistance. We would also like to thank all participants. This study was performed with the support of the Murdoch Childrens Research Institute Clinical Science theme funding. This study was supported by the Victorian Government's Operational Infrastructure Support Program.