Journal article

Differences in the resting platelet proteome and platelet releasate between healthy children and adults

Charmaine Cini, Christina Yip, Chantal Attard, Vasiliki Karlaftis, Paul Monagle, Matthew Linden, Vera Ignjatovic

JOURNAL OF PROTEOMICS | ELSEVIER | Published : 2015

Abstract

UNLABELLED: Major age-related diseases such as cardiovascular disease and cancer are the primary causes of morbidity and mortality in Australia and worldwide. In our recent study characterising differences in the plasma proteome between healthy children and adults, a large number of proteins differentially expressed with age were found to be of platelet origin. This study aimed to characterise differences in the resting platelet proteome and the platelet releasate of healthy children compared to healthy adults. This study represents the setup of a procedure for the proteomic analysis of platelets from children. Differentially expressed platelet proteins were identified using Two-dimensional ..

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