Journal article

Rate of Change in Renal Function and Mortality in Elderly Treated Hypertensive Patients

Enayet K Chowdhury, Robyn G Langham, Zanfina Ademi, Alice Owen, Henry Krum, Lindon MH Wing, Mark R Nelson, Christopher M Reid

Clinical Journal of the American Society of Nephrology | AMER SOC NEPHROLOGY | Published : 2015

Abstract

BACKGROUND AND OBJECTIVES: Evidence relating the rate of change in renal function, measured as eGFR, after antihypertensive treatment in elderly patients to clinical outcome is sparse. This study characterized the rate of change in eGFR after commencement of antihypertensive treatment in an elderly population, the factors associated with eGFR rate change, and the rate's association with all-cause and cardiovascular mortality. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Data from the Second Australian National Blood Pressure study were used, where 6083 hypertensive participants aged ≥65 years were enrolled during 1995-1997 and followed for a median of 4.1 years (in-trial). Following the Se..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by National Health and Medical Research Council (NHMRC)


Funding Acknowledgements

ANBP2 was supported by the Australian Commonwealth Department of Health and Aging, National Health and Medical Research Council of Australia (grant 546272), and Merck Sharp & Dohme (Australia). The ANBP2 cohort follow-up study was supported by a National Health and Medical Research Council (NHMRC) Program grant (546272) awarded to C.M.R., who is supported by a NHMRC Research Fellowship (1045862). In addition, E.K.C. has been awarded a Monash University Postgraduate Publication Award to finalize the current work.