Journal article

The risk of oesophago-gastric cancer in symptomatic patients in primary care: a large case-control study using electronic records

S Stapley, TJ Peters, RD Neal, PW Rose, FM Walter, W Hamilton

BRITISH JOURNAL OF CANCER | NATURE PUBLISHING GROUP | Published : 2013

Abstract

BACKGROUND: Over 15 000 new oesophago-gastric cancers are diagnosed annually in the United Kingdom, with most being advanced disease. We identified and quantified features of this cancer in primary care. METHODS: Case-control study using electronic primary-care records of the UK patients aged ≥40 years was performed. Cases with primary oesophago-gastric cancer were matched to controls on age, sex and practice. Putative features of cancer were identified in the year before diagnosis. Odds ratios (ORs) were calculated for these features using conditional logistic regression, and positive predictive values (PPVs) were calculated. RESULTS: A total of 7471 cases and 32 877 controls were studied. ..

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University of Melbourne Researchers

Grants

Awarded by National Institute for Health Research


Funding Acknowledgements

We thank for the contribution provided by the Discovery Programme Steering Committee comprising: Roger Jones (Chair), Jonathan Banks, Alison Clutterbuck, Jon Emery, Joanne Hartland, Sandra Hollinghurst, Maire Justice, Jenny Knowles, Helen Morris, Greg Rubin. This study was funded by the NIHR Programme Grants for Applied Research funding scheme. The study was approved by the Independent Scientific Advisory Committee (ISAC).