Journal article

EFFECT OF VELOCITY PROFILE SKEWING ON BLOOD VELOCITY AND VOLUME FLOW WAVEFORMS DERIVED FROM MAXIMUM DOPPLER SPECTRAL VELOCITY

Jonathan P Mynard, David A Steinman

ULTRASOUND IN MEDICINE AND BIOLOGY | ELSEVIER SCIENCE INC | Published : 2013

Abstract

Given evidence that fully developed axisymmetric flow may be the exception rather than the rule, even in nominally straight arteries, maximum velocity (V(max)) can lie outside the Doppler sample volume (SV). The link between V(max) and derived quantities, such as volume flow (Q), may therefore be more complex than commonly thought. We performed idealized virtual Doppler ultrasound on data from image-based computational fluid dynamics (CFD) models of the normal human carotid artery and investigated how velocity profile skewing and choice of sample volume affected V(max) waveforms and derived Q variables, considering common assumptions about velocity profile shape (i.e., Poiseuille or Womersle..

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Grants

Awarded by Heart and Stroke Foundation of Canada


Awarded by National Institute on Aging, the National Institutes of Health (NIH)


Funding Acknowledgements

The authors thank Prof. Richard Cobbold and Dr. Luis Aguilar for helpful discussions about ultrasound. This work was supported by grant NA-6727 to D. A. S. from the Heart and Stroke Foundation of Canada. The VALIDATE study is supported by Contract No. NO1-AG-3-1003 from the National Institute on Aging, the National Institutes of Health (NIH) and, in part, by the Intramural Research Program of the National Institute on Aging, NIH. J.P.M. acknowledges the support of an Overseas Biomedical Training Fellowship from the National Health and Medical Research Council of Australia. D.A.S. acknowledges the support of a Heart and Stroke Foundation Career Investigator Award.