Journal article

Errors in the estimation of wall shear stress by maximum Doppler velocity

Jonathan P Mynard, Bruce A Wasserman, David A Steinman

ATHEROSCLEROSIS | ELSEVIER IRELAND LTD | Published : 2013

Abstract

OBJECTIVE: Wall shear stress (WSS) is an important parameter with links to vascular (dys)function. Difficult to measure directly, WSS is often inferred from maximum spectral Doppler velocity (Vmax) by assuming fully-developed flow, which is valid only if the vessel is long and straight. Motivated by evidence that even slight/local curvatures in the nominally straight common carotid artery (CCA) prevent flow from fully developing, we investigated the effects of velocity profile skewing on Vmax-derived WSS. METHODS: Velocity profiles, representing different degrees of skewing, were extracted from the CCA of image-based computational fluid dynamics (CFD) simulations carried out as part of the V..

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Grants

Awarded by Heart & Stroke Foundation of Canada


Awarded by National Institute on Aging, NIH


Awarded by NATIONAL INSTITUTE ON AGING


Funding Acknowledgements

This work was supported by grant NA6727 from the Heart & Stroke Foundation of Canada. The VALIDATE study is supported by Contract No. NO1-AG-3-1003 from the National Institute on Aging, NIH and, in part, by the Intramural Research Program of the National Institute on Aging, NIH. JPM was supported by an Overseas Biomedical Training Fellowship from the National Health and Medical Research Council of Australia. DAS was supported by a Heart and Stroke Foundation Career Investigator Award.