Journal article

A minimal or maximal ablation strategy to achieve pulmonary vein isolation for paroxysmal atrial fibrillation: a prospective multi-centre randomized controlled trial (the Minimax study)

Alex JA McLellan, Liang-Han Ling, Sonia Azzopardi, Geraldine A Lee, Geoffrey Lee, Saurabh Kumar, Michael CG Wong, Tomos E Walters, Justin M Lee, Khang-Li Looi, Karen Halloran, Martin K Stiles, Nigel A Lever, Simon P Fynn, Patrick M Heck, Prashanthan Sanders, Joseph B Morton, Jonathan M Kalman, Peter M Kistler

European Heart Journal | OXFORD UNIV PRESS | Published : 2015


AIMS: Pulmonary vein isolation (PVI) is the cornerstone of catheter ablation of atrial fibrillation (AF). The intervenous ridge (IVR) may be incorporated into ablation strategies to achieve PVI; however, randomized trials are lacking. We performed a randomized multi-centre international study to compare the outcomes of (i) circumferential antral PVI (CPVI) alone (minimal) vs. (ii) CPVI with IVR ablation to achieve individual PVI (maximal). METHODS AND RESULTS: Two hundred and thirty-four patients with paroxysmal AF underwent CPVI and were randomized to a minimal or maximal ablation strategy. The primary outcome of recurrent atrial arrhythmia was assessed with 7-day Holter monitoring at 6 and..

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Funding Acknowledgements

Dr McLellan is supported by an Australian National Health and Medical Research Council (NHMRC)/Australian National Heart Foundation (NHF) Postgraduate Scholarship, and BakerIDI Scholarship. Dr Ling and Dr Wong are supported by Australian NHF Postgraduate Scholarships. Dr Walters is supported by an Australian NHMRC Postgraduate Research Scholarship. Dr G. Lee and Dr Kumar are supported by NHMRC Early Career Fellowships. Dr Sanders is supported by the NHF. Drs Sanders, Kalman, and Kistler are supported by practitioner fellowships from the NHMRC. This research is supported in part by the Victorian Government's Operational Infrastructure.