Journal article

Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin

Natalya Lukoyanova, Stephanie C Kondos, Irene Farabella, Ruby HP Law, Cyril F Reboul, Tom T Caradoc-Davies, Bradley A Spicer, Oded Kleifeld, Daouda AK Traore, Susan M Ekkel, Ilia Voskoboinik, Joseph A Trapani, Tamas Hatfaludi, Katherine Oliver, Eileen M Hotze, Rodney K Tweten, James C Whisstock, Maya Topf, Helen R Saibil, Michelle A Dunstone

PLOS Biology | PUBLIC LIBRARY SCIENCE | Published : 2015


Awarded by Wellcome Trust

Awarded by BBSRC

Awarded by ERC

Awarded by Leverhulme Trust

Awarded by Australian Research Council (ARC)

Awarded by National Health and Medical Research Council

Awarded by Biotechnology and Biological Sciences Research Council

Funding Acknowledgements

HRS acknowledges support from the Wellcome Trust (grant 079605/2/06/2) for EM facilities and doctoral training support to KO (MRC G1001602), the BBSRC (BB/D00873/1) and the ERC (294408). MT acknowledges the BBSRC (BB/K01692X/1) and Leverhulme Trust (RPG-2012-519). We thank D. Houldershaw and R. Westlake for computing support, L. Wang for EM support, and E.V. Orlova, D.K. Clare and A.P. Pandurangan for discussion. MAD is a National Health and Medical Research Council of Australia (NHMRC) Career Development Fellow. MAD acknowledges support from the Australian Research Council (ARC) [DP120104058, DP0986811, CE140100011] and the National Health and Medical Research Council [606471]. JCW is an NHMRC Senior Principal Research Fellow. JCW also acknowledges the support of an Australian Research Council Federation Fellowship. CFR is supported by the Australian Postgraduate Award. DT acknowledges the support of an ARC Super Science Fellowship. RKT acknowledges the National Institutes of Health, NIAID [AI037657]. The authors acknowledge the support of the Victorian Life Sciences Computation Initiative (VLSCI, Melbourne, Australia) and the Multi-modal Australian ScienceS Imaging and Visualisation Environment (MASSIVE) ( The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.