Influx mechanisms in the embryonic and adult rat choroid plexus: a transcriptome study
Norman R Saunders, Katarzyna M Dziegielewska, Kjeld Mollgard, Mark D Habgood, Matthew J Wakefield, Helen Lindsay, Nathalie Stratzielle, Jean-Francois Ghersi-Egea, Shane A Liddelow
FRONTIERS IN NEUROSCIENCE | FRONTIERS MEDIA SA | Published : 2015
The transcriptome of embryonic and adult rat lateral ventricular choroid plexus, using a combination of RNA-Sequencing and microarray data, was analyzed by functional groups of influx transporters, particularly solute carrier (SLC) transporters. RNA-Seq was performed at embryonic day (E) 15 and adult with additional data obtained at intermediate ages from microarray analysis. The largest represented functional group in the embryo was amino acid transporters (twelve) with expression levels 2-98 times greater than in the adult. In contrast, in the adult only six amino acid transporters were up-regulated compared to the embryo and at more modest enrichment levels (<5-fold enrichment above E15)...View full abstract
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Awarded by National Health and Medical Research Council (Australia)
Awarded by European Union Seventh Framework Program (FP7) Neurobid consortium
KD, MH and NRS are supported by the National Health and Medical Research Council (Australia) - Grants No.567205 and 1049287. SL, KD, NRS, NS and J-FG-E were supported by the European Union Seventh Framework Program (FP7) Neurobid consortium - Agreement No. HEALTH-F2-2009-241778, J-FG-E is supported by ANR-10-IBHU-0003 Cesame grant, SL was supported as a Neurological Fellow by the American-Australian Association and as an NHMRC CJ Martin Fellow.