Journal article

Thrombosis in Paediatrics: Genetic versus Environmental Risk Factors and Implications for Management

Paul Monagle, AE Thomas (ed.), C Halsey (ed.)

CONTROVERSIES IN PEDIATRIC AND ADOLESCENT HEMATOLOGY | KARGER | Published : 2014

Abstract

Virchow, the famous German pathologist, described the three critical factors for the development of thrombosis as being disturbances in blood flow, abnormalities in the blood vessel wall, and disturbances in the blood constituents that led to hypercoagulability. Over 150 years later, this triad remains perhaps the most useful way to think about risk factors for thrombosis, and to consider the relative contributions of genetic versus environmental factors contributing to thrombosis. As will be demonstrated throughout this chapter, environmental risk factors seem far more important to the aetiology, presentation, and management of thrombosis in children than do genetic factors. One cannot conc..

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