Journal article

Contrast-enhanced ultrasonography to evaluate changes in renal cortical microcirculation induced by noradrenaline: a pilot study

Antoine G Schneider, Mark D Goodwin, Anthony Schelleman, Michael Bailey, Lynne Johnson, Rinaldo Bellomo

Critical Care (UK) | BMC | Published : 2014

Abstract

INTRODUCTION: We used contrast-enhanced ultrasound (CEUS) to estimate the effect of an increase in mean arterial pressure (MAP) induced by noradrenaline infusion on renal microvascular cortical perfusion in critically ill patients. METHODS: Twelve patients requiring a noradrenaline infusion to maintain a MAP more than 60 mmHg within 48 hours of intensive care unit admission were included in the study. Renal CEUS scans with destruction-replenishment sequences and Sonovue® (Bracco, Milano Italy) as a contrast agent, were performed at baseline (MAP 60 to 65 mmHg) and after a noradrenaline-induced increase in MAP to 80 to 85 mmHg. RESULTS: There was no adverse effect associated with ultrasound c..

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University of Melbourne Researchers