Journal article

Predictors of Respiratory-induced Lung Tumour Motion Measured on Four-dimensional Computed Tomography

KV Tan, R Thomas, N Hardcastle, D Pham, T Kron, F Foroudi, D Ball, L te Marvelde, M Bressel, S Siva

CLINICAL ONCOLOGY | ELSEVIER SCIENCE LONDON | Published : 2015

Abstract

AIMS: The delivery of radical radiotherapy in lung cancer is complicated by respiratory-induced tumour motion. The aim of the study was to correlate tumour motion characteristics with tumour and patient factors, particularly the anatomical lobe and pulmonary zone. MATERIALS AND METHODS: Lung tumour volumes on four-dimensional computed tomography were delineated by a single observer at maximal expiration and propagated through all 10 phases of the breathing cycle. Movements were tracked in the superior-inferior (SI), anterior-posterior (AP) and medio-lateral (ML) directions by changes in the tumour centroid coordinates. Tumour motion characteristics were correlated with anatomical lobe, pulmo..

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