Journal article

Association of in vitro fertilization with global and IGF2/H19 methylation variation in newborn twins

YJ Loke, JC Galati, R Saffery, JM Craig

JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE | CAMBRIDGE UNIV PRESS | Published : 2015

Abstract

In vitro fertilization (IVF) and its subset intracytoplasmic sperm injection (ICSI), are widely used medical treatments for conception. There has been controversy over whether IVF is associated with adverse short- and long-term health outcomes of offspring. As with other prenatal factors, epigenetic change is thought to be a molecular mediator of any in utero programming effects. Most studies focused on DNA methylation at gene-specific and genomic level, with only a few on associations between DNA methylation and IVF. Using buccal epithelium from 208 twin pairs from the Peri/Postnatal Epigenetic Twin Study (PETS), we investigated associations between IVF and DNA methylation on a global level..

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Grants

Awarded by Australian National Health and Medical Research Council


Awarded by Financial Markets Foundation for Children


Funding Acknowledgements

This work was supported by grants from the Australian National Health and Medical Research Council (grant numbers 437015, 607358 to Jeffrey M. Craig and Richard Saffery); the Financial Markets Foundation for Children (grant number 032-2007); and the Victorian Government's Operational Infrastructure Support Program. The authors have no competing financial interests.