Journal article

Incidence, Spectrum and Outcome of Immune Reconstitution Syndrome in HIV-infected Children after Initiation of Antiretroviral Therapy

Despoina Gkentzi, Marc Tebruegge, Gareth Tudor-Williams, Sam Walters, Hermione Lyall, Mike Sharland, Katja Doerholt

PEDIATRIC INFECTIOUS DISEASE JOURNAL | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014

Abstract

BACKGROUND: Immune reconstitution syndrome (IRS) is a relatively common complication in HIV-infected adults starting combination antiretroviral therapy (cART). Data on IRS in HIV-infected children remain limited and are largely restricted to resource-limited settings. This study investigated the incidence, spectrum and outcome of IRS in a pediatric cohort in the United Kingdom. METHODS: Retrospective analysis of clinical events during the first 12 months after initiation of cART in 135 treatment-naïve, HIV-infected children in the United Kingdom over a 5-year period. Demographic and laboratory data were provided by the Collaborative HIV Paediatric Study. RESULTS: The median age at cART initi..

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