Journal article
Knocking down schistosomes - promise for lentiviral transduction in parasites
J Hagen, JPY Scheerlinck, RB Gasser
Trends in Parasitology | ELSEVIER SCI LTD | Published : 2015
Abstract
Underpinned by major advances in our understanding of the genomes of schistosomes, progress in the development of functional genomic tools is providing unique prospects to gain insights into the intricacies of the biology of these blood flukes, their host relationships, and the diseases that they cause. This article reviews some key applications of double-stranded RNA interference (RNAi) in Schistosoma mansoni, appraises delivery systems for transgenesis and stable gene silencing, considers ways of increasing efficiency and specificity of gene silencing, and discusses the prospects of using a lentivirus delivery system for future functional genomic-phenomic explorations of schistosomes and o..
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Awarded by Australian Research Council
Funding Acknowledgements
Funding from the National Health and Medical Research Council (NHMRC) and the Australian Research Council (ARC) is gratefully acknowledged. This project was also partially supported by a Victorian Life Sciences Computation Initiative (VLSCI; grant VR0007) on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government. The authors thank colleagues who contributed to the research of J.H. [61]. J.H. was a grateful recipient of Melbourne International Research Scholarships (MIRS and MIFRS) from the University of Melbourne.