Journal article

Is the logopenic-variant of primary progressive aphasia a unitary disorder?

Cristian E Leyton, John R Hodges, Catriona A McLean, Jillian J Kril, Olivier Piguet, Kirrie J Ballard

CORTEX | ELSEVIER MASSON, CORPORATION OFFICE | Published : 2015

Abstract

Logopenic progressive aphasia is one of the clinical presentations of primary progressive aphasia and formally defined by the co-occurrence of impaired naming and sentence repetition. Impaired naming is attributed to failure of lexical retrieval, which is a multi-staged process subserved by anatomically segregated brain regions. By dissecting the neurocognitive processes involved in impaired naming, we aimed to disentangle the clinical and neuroanatomical heterogeneity of this syndrome. Twenty-one individuals (66.7% females, age range 53-83 years) who fulfilled diagnostic criteria for logopenic variant and had at least two clinical and language assessments, 1 year apart, were recruited and m..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) project grant


Awarded by NHMRC program grant


Awarded by Australian Research Council (ARC) Centre of Excellence in Cognition and its Disorders


Awarded by Sydney University Postdoctoral Fellowship


Awarded by ARC Future Fellowship


Awarded by ARC Federation Fellowship


Awarded by NHMRC Career Development Fellowship


Funding Acknowledgements

This work was supported by a National Health and Medical Research Council (NHMRC) project grant (630489); an NHMRC program grant (APP1037746); the Australian Research Council (ARC) Centre of Excellence in Cognition and its Disorders (CE110001021); a Sydney University Postdoctoral Fellowship (U2644 to C.E.L.); an ARC Future Fellowship (FT120100355 to K.J.B.); an ARC Federation Fellowship (FF0776229 to J.R.H.); and an NHMRC Career Development Fellowship (APP1022684 to O.P.).