Journal article

N-Acetyl Cysteine in the Treatment of Obsessive Compulsive and Related Disorders: A Systematic Review

Georgina Oliver, Olivia Dean, David Camfield, Scott Blair-West, Chee Ng, Michael Berk, Jerome Sarris

CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE | KOREAN COLL NEUROPSYCHOPHARMACOLOGY | Published : 2015

Abstract

OBJECTIVE: Obsessive compulsive and related disorders are a collection of debilitating psychiatric disorders in which the role of glutamate dysfunction in the underpinning neurobiology is becoming well established. N-acetyl cysteine (NAC) is a glutamate modulator with promising therapeutic effect. This paper presents a systematic review of clinical trials and case reports exploring the use of NAC for these disorders. A further objective was to detail the methodology of current clinical trials being conducted in the area. METHODS: PubMed, Web of Science and Cochrane Library Database were searched for human clinical trials or case reports investigating NAC in the treatment of obsessive compuls..

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