Journal article
Introduction of universal prestorage leukodepletion of blood components, and outcomes in transfused cardiac surgery patients
ZK McQuilten, N Andrianopoulos, L Van De Watering, C Aubron, L Phillips, R Bellomo, D Pilcher, P Cameron, CM Reid, MF Cole-Sinclair, A Newcomb, J Smith, JJ McNeil, EM Wood
Journal of Thoracic and Cardiovascular Surgery | Published : 2015
Abstract
Objective To assess whether introduction of universal leukodepletion (ULD) of red blood cells (RBCs) for transfusion was associated with improvements in cardiac surgery patient outcomes. Methods Retrospective study (2005-2010) conducted at 6 institutions. Associations between leukodepletion and outcomes of mortality, infection, and acute kidney injury (AKI) were modeled by logistic regression, and intensive care unit length of stay (LOS) in survivors was explored using linear regression. To examine trends over time, odds ratios (ORs) for outcomes of transfused were compared with nontransfused patients, including a comparison with nontransfused patients who were selected based on propensity s..
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Awarded by Department of Health, State Government of Victoria
Funding Acknowledgements
Z.M. is the recipient of an Australian National Health and Medical Research Council (NHMRC) Postgraduate Scholarship (APP1017942). C.R. is the recipient of an Australian NHMRC Senior Research Fellowship (APP 1045862). This project was funded as part of an Australian NHMRC Partnership grant between the Australian Red Cross Blood Service, the Victorian Government Department of Health, and Monash University: NHMRC ID Number 546291. Australian governments fully fund the Australian Red Cross Blood Service for the provision of blood products and services to the Australian Community. The ANZSCTS National Cardiac Surgery Database Program is funded by the Department of Health Victoria, and the Health Administration Corporation and the Clinical Excellence Commission, New South Wales.