Effect of Mesenchymal Precursor Cells on the Systemic Inflammatory Response and Endothelial Dysfunction in an Ovine Model of Collagen-Induced Arthritis
Laura M Dooley, Anwar Abdalmula, Elizabeth A Washington, Claire Kaufman, Elizabeth M Tudor, Peter Ghosh, Silviu Itescu, Wayne G Kimpton, Simon R Bailey
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2015
BACKGROUND AND AIM: Mesenchymal precursor cells (MPC) are reported to possess immunomodulatory properties that may prove beneficial in autoimmune and other inflammatory conditions. However, their mechanism of action is poorly understood. A collagen-induced arthritis model has been previously developed which demonstrates local joint inflammation and systemic inflammatory changes. These include not only increased levels of inflammatory markers, but also vascular endothelial cell dysfunction, characterised by reduced endothelium-dependent vasodilation. This study aimed to characterise the changes in systemic inflammatory markers and endothelial function following the intravenous administration ..View full abstract
Funding: This study was funded by Mesoblast Ltd. Co-authors PG and SI received salary from Mesoblast Ltd. Co-authors PG and SI, representing Mesoblast Ltd., had a role in the initial study design and protocol, and in the preparation of the manuscript. LMD was supported by an Australian Postgraduate Award scholarship.