Journal article

Contribution of the hypothalamus and gut to weight gain susceptibility and resistance in mice

Barbara C Fam, Rebecca Sgambellone, Zheng Ruan, Joseph Proietto, Sofianos Andrikopoulos



Obesity susceptibility in humans and in rodent strains varies in response to the consumption of high-energy density (HED) diets. However, the exact mechanism(s) involved in this susceptibility remain(s) unresolved. The aim of the present study was to gain greater insight into this susceptibility by using C57BL/6J (B6) mice that were separated into obesity-prone (diet-induced obese (DIO)) and obesity-resistant (diet-induced resistant (DR)) groups following an HED diet for 6 weeks. Physiological, biochemical and gene expression assessments of energy balance were performed in the DIO and DR mice on an HED diet and chow-fed mice. The increased weight gain of the DIO mice as compared to the DR mi..

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study was funded by seeding grants from the Diabetes Australia Research Trust (to B C F), the Sir Edward Dunlop Medical Research Foundation (to B C F), the Austin Health Medical Research Foundation (to B C F) and the University of Melbourne (to B C F) and by the National Health and Medical Research Council (app number 1060173).