BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells
Emma K Baker, Scott Taylor, Ankita Gupte, Phillip P Sharp, Mannu Walia, Nicole C Walsh, Andrew CW Zannettino, Alistair M Chalk, Christopher J Burns, Carl R Walkley
Scientific Reports | NATURE PUBLISHING GROUP | Published : 2015
We thank Peter Houghton (Nationwide Children's Hospital, Ohio) for generously sharing human OS xenograft material; SVH BioResources Centre; Assoc Prof Jock Campbell for assistance with statistical analyses; Ms Shreya Bhattacharya for technical assistance; Dr Monique Smeets for comments and discussion; SVI Flow Cytometry Facility (M Thomson and E Orlowski) for assistance with FACS analysis. This work was supported by grants from the Cancer Council of Victoria (to C.W. and E.B.); NHMRC Career Development Award (to C.W.); Zig Inge Foundation (to C.W.); Cure Cancer Australia Foundation (to E.B); 5point foundation (to E.B and C.W.); in part by the Victorian State Government Operational Infrastructure Support Program (to St. Vincent's Institute). C.W. is the Philip Desbrow Senior Research Fellow of the Leukaemia Foundation.