Angiotensin II increases nerve-evoked contractions in mouse tail artery by a T-type Ca2 channel-dependent mechanism
Trent F Reardon, Brid P Callaghan, James A Brock
EUROPEAN JOURNAL OF PHARMACOLOGY | ELSEVIER SCIENCE BV | Published : 2015
Angiotensin II (Ang II) increases sympathetic nerve-evoked contractions of arterial vessels. Here the mechanisms underlying this effect were investigated in mouse tail artery. Isometrically mounted segments of mouse distal tail artery were used to investigate the effects of endothelium denudation, blocking Ca(2+) channels and inhibiting superoxide signalling on Ang II-induced facilitation of nerve-evoked contractions. In addition, in situ amperometry was used to assess effects of Ang II on noradrenaline release. Ang II (0.1-1nM) increased nerve-evoked contractions but did not change noradrenaline release. Losartan (Ang II type 1 receptor antagonist), but not PD 123319 (Ang II type 2 receptor..View full abstract
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Awarded by Grant from the National Health and Medical Research Council of Australia
The work was supported by a Grant from the National Health and Medical Research Council of Australia (Grant number 568850).