Journal article

Unaccustomed Eccentric Contractions Impair Plasma K Regulation in the Absence of Changes in Muscle Na , K - ATPase Content

Craig A Goodman, Jason A Bennie, Murray J Leikis, Michael J McKenna

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2014

Abstract

The Na+,K+-ATPase (NKA) plays a fundamental role in the regulation of skeletal muscle membrane Na+ and K+ gradients, excitability and fatigue during repeated intense contractions. Many studies have investigated the effects of acute concentric exercise on K+ regulation and skeletal muscle NKA, but almost nothing is known about the effects of repeated eccentric contractions. We therefore investigated the effects of unaccustomed maximal eccentric knee extensor contractions on K+ regulation during exercise, peak knee extensor muscle torque, and vastus lateralis muscle NKA content and 3-O-MFPase activity. Torque measurements, muscle biopsies, and venous blood samples were taken before, during and..

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University of Melbourne Researchers