Journal article
RARγ is a negative regulator of osteoclastogenesis
AC Green, IJ Poulton, C Vrahnas, KD Häusler, CR Walkley, JY Wu, TJ Martin, MT Gillespie, RAS Chandraratna, JMW Quinn, NA Sims, LE Purton
Journal of Steroid Biochemistry and Molecular Biology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2015
Abstract
Vitamin A is known to influence post-natal bone content, with excess intake being associated with reduced bone mineral density and increased fracture risk. Despite this, the roles retinoids play in regulating osteoclastogenesis, particularly in vivo, remain unresolved. This study therefore aimed to determine the effect of loss of retinoic acid receptors (RAR)α or RARγ on bone mass (analyzed by histomorphometry and dual-energy X-ray absorptiometry) and osteoclastogenesis in mice in vivo. RARγ null mice had significantly less trabecular bone at 8 weeks of age compared to wildtype littermates. In contrast, no change in trabecular bone mass was detected in RARα null mice at this age. Further his..
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Awarded by National Institutes of Health
Funding Acknowledgements
We thank P. Chambon for providing the RAR knockout mice. This work was supported by the Cancer Council of Victoria (L.E.P.), project grants from the National Health and Medical Research Council (NHMRC) (to L.E.P. and to J.M.W.Q and M.T.G.), the National Institutes of Health DK-071773 (L.E.P.), the Operational Infrastructure Support Scheme from the Victorian State Government (to St. Vincent's Institute), and an NHMRC Program Grant to N.A.S., and M.T.G.; L.E.P and N.A.S are Senior Research Fellows of the NHMRC.