Journal article

IAP gene deletion and conditional knockout models

John Silke, David L Vaux

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2015

Abstract

Gene deletion studies have helped reveal the unique and overlapping roles played by IAP proteins. Crossing IAP mutant mice has helped unravel the complex feed-back regulatory circuits in which cIAP1, cIAP2 and XIAP allow innate defensive responses to microbial pathogens, without the development of auto-inflammatory syndromes. Deletion of genes for Survivin and its homologs in yeasts, invertebrates and mammals has shown that it functions differently, as it is not a regulator of innate immunity or apoptosis, but acts together with INCENP, aurora kinase B and Borealin to allow chromosome segregation during mitosis.

Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by NHMRC Independent Research Institute Infrastructure Support Grant


Funding Acknowledgements

This work was supported by National Health and Medical Research Council (NHMRC) Grants 596822, 541902, 1016701 and fellowships to DLV (1020136) and JS (541901, 1058190). Additional support was obtained from the Australian Cancer Research Fund, Victorian State Government Operational Infrastructure Support, and NHMRC Independent Research Institute Infrastructure Support Grant 361646.