Journal article

Childhood Hospitalisation with Infection and Cardiovascular Disease in Early-Mid Adulthood: A Longitudinal Population-Based Study

David P Burgner, Matthew N Cooper, Hannah C Moore, Fiona J Stanley, Peter L Thompson, Nicholas H de Klerk, Kim W Carter

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2015


BACKGROUND: Pathogen-specific and overall infection burden may contribute to atherosclerosis and cardiovascular disease (CVD), but the effect of infection severity and timing is unknown. We investigated whether childhood infection-related hospitalisation (IRH, a marker of severity) was associated with subsequent adult CVD hospitalisation. METHODS: Using longitudinal population-based statutorily-collected administrative health data from Western Australia (1970-2009), we identified adults hospitalised with CVD (ischaemic heart disease, ischaemic stroke, and peripheral vascular disease) and matched them (10:1) to population controls. We used Cox regression to assess relationships between number..

View full abstract


Awarded by National Health and Medical Research Council, Australia

Awarded by National Heart Foundation, Australia

Funding Acknowledgements

The research was supported by the Victorian Government's Operational Infrastructure Support Program and a University of Western Australia Research Development Award. DPB is supported by a Senior Research Fellowship from the National Health and Medical Research Council (APP1064629), Australia and by an honorary Future Leader Fellowship from the National Heart Foundation (100026), Australia. HCM is supported by an Early Career Fellowship from the National Health and Medical Research Council, Australia. KWC is supported by the McCusker Charitable Foundation Bioinformatics Centre. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.