Journal article
An adipogenic gel for surgical reconstruction of the subcutaneous fat layer in a rat model
H Debels, YW Gerrand, CJ Poon, KM Abberton, WA Morrison, GM Mitchell
Journal of Tissue Engineering and Regenerative Medicine | WILEY | Published : 2017
DOI: 10.1002/term.2025
Abstract
‘Off-the-shelf’ tissue-engineered skin alternatives for epidermal and dermal skin layers are available; however, no such alternative for the subdermal fat layer exists. Without this well-vascularized layer, skin graft take is variable and grafts may have reduced mobility, contracture and contour defects. In this study a novel adipose-derived acellular matrix (Adipogel) was investigated for its properties to generate subdermal fat in a rat model. In a dorsal thoracic site, a 1 × 1 cm Adipogel implant was inserted within a subdermal fat layer defect. In a dorsal lumbar site, an Adipogel implant was inserted in a subfascial pocket. Contralateral control defects remained empty. At 8 weeks wound/..
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Awarded by Jack Brockhoff Foundation
Funding Acknowledgements
The authors would like to thank the Experimental and Surgical Research Unit staff at St. Vincent's Hospital, Melbourne: Sue McKay, Liliana Pepe, Amanda Rixon and Anna Deftereos. We would also like to thank Mr Jason Palmer (O'Brien Institute) for technical assistance. The authors also gratefully achnowledge Professor Moustapha Hamdi, Head of the Department of Plastic and Reconstructive Surgery, Brussels University Hospital, Belgium, for his collaboration with the O'Brien Institute, and for encouraging Dr Heidi Debels to study at the O'Brien Institute. This work was supported by the National Medical and Research Council of Australia (Project Grant No. APP 1076846) and by a Jack Brockhoff Foundation Medical Grant. We gratefully acknowledge funding support from a Victorian State Government Grant for the Neopec Technology through its Science, Technology and Innovation Programme. The authors also acknowledge the assistance of the Victorian State Government's Department of Innovation, Industry and Regional Development's Operational Infrastructure Support Programme.