Journal article

Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome

Nicolas Cenac, Tereza Bautzova, Pauline Le Faouder, Nicholas A Veldhuis, Daniel P Poole, Corinne Rolland, Jessica Bertrand, Wolfgang Liedtke, Marc Dubourdeau, Justine Bertrand-Michel, Lisa Zecchi, Vincenzo Stanghellini, Nigel W Bunnett, Giovanni Barbara, Nathalie Vergnolle



BACKGROUND & AIMS: In mice, activation of the transient receptor potential cation channels (TRP) TRPV1, TRPV4, and TRPA1 causes visceral hypersensitivity. These receptors and their agonists might be involved in development of irritable bowel syndrome (IBS). We investigated whether polyunsaturated fatty acid (PUFA) metabolites, which activate TRPs, are present in colon tissues from patients with IBS and act as endogenous agonists to induce hypersensitivity. METHODS: We analyzed colon biopsy samples from 40 patients with IBS (IBS biopsies) and 11 healthy individuals undergoing colorectal cancer screening (controls), collected during colonoscopy at the University of Bologna, Italy. Levels of th..

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University of Melbourne Researchers


Awarded by European Research Council

Funding Acknowledgements

This work was supported by the Institut UPSA de la Douleur (to Nicolas Cenac), the Agence Nationale de la Recherche (to Nicolas Cenac, Nathalie Vergnolle), the Canadian Institute of Health Research (to Nathalie Vergnolle), the Region Midi-Pyrenees (to Pauline Le Faouder, Marc Dubourdeau, Nicolas Cenac, and Nathalie Vergnolle) and by the European Research Council (ERC-2012-StG-20111109), the Italian Ministry of University and Research and the University of Bologna, Italy (to Giovanni Barbara and Vincenzo Stanghellini).