Mouse pancreatic beta cells express MHC class II and stimulate CD4( ) T cells to proliferate
Yuxing Zhao, Nicholas A Scott, Hong Sheng Quah, Balasubramanian Krishnamurthy, Francene Bond, Thomas Loudovaris, Stuart I Mannering, Thomas WH Kay, Helen E Thomas
EUROPEAN JOURNAL OF IMMUNOLOGY | WILEY-BLACKWELL | Published : 2015
Type 1 diabetes results from destruction of pancreatic beta cells by autoreactive T cells. Both CD4(+) and CD8(+) T cells have been shown to mediate beta-cell killing. While CD8(+) T cells can directly recognize MHC class I on beta cells, the interaction between CD4(+) T cells and beta cells remains unclear. Genetic association studies have strongly implicated HLA-DQ alleles in human type 1 diabetes. Here we studied MHC class II expression on beta cells in nonobese diabetic mice that were induced to develop diabetes by diabetogenic CD4(+) T cells with T-cell receptors that recognize beta-cell antigens. Acute infiltration of CD4(+) T cells in islets occurred with rapid onset of diabetes. Beta..View full abstract
Awarded by National Health and Medical Research Council of Australia (NHMRC)
This work was funded by a National Health and Medical Research Council of Australia (NHMRC) Project grant (APP1061961), Program grant (APP1037321), and fellowships from the NHMRC (HET) and JDRF (Y.Z., B.K., and S.I.M.). The St. Vincent's Institute receives support from the Operational Infrastructure Support Scheme of the Government of Victoria.