Journal article

The androgen receptor has no direct antiresorptive actions in mouse osteoclasts

Mieke Sinnesael, Ferran Jardi, Ludo Deboel, Michael R Laurent, Vanessa Dubois, Jeffrey D Zajac, Rachel A Davey, Geert Carmeliet, Frank Claessens, Dirk Vanderschueren

MOLECULAR AND CELLULAR ENDOCRINOLOGY | ELSEVIER IRELAND LTD | Published : 2015

Abstract

Androgen deficiency or androgen receptor knockout (ARKO) causes high-turnover osteopenia, but the target cells for this effect remain unclear. To examine whether AR in osteoclasts directly suppresses bone resorption, we crossed AR-floxed with cathepsin K-Cre mice. Osteoclast-specific ARKO (ocl-ARKO) mice showed no changes neither in osteoclast surface nor in bone microarchitecture nor in the response to orchidectomy and androgen replacement, indicating that the AR in osteoclasts is not critical for bone maintenance. In line with the lack of a bone phenotype, the levels of AR were very low in osteoclast-enriched cultures derived from bone marrow (BM) and undetectable in osteoclasts generated ..

View full abstract