Common polymorphisms in the CD43 gene region are associated with tuberculosis disease and mortality

M Campo; AK Randhawa; S Dunstan; J Farrar; M Caws; ND Bang; NN Lan; TTH Chau; DJ Horne; NT Thuong; GE Thwaites; TR Hawn

Journal article

Common polymorphisms in the CD43 gene region are associated with tuberculosis disease and mortality

M Campo, AK Randhawa, S Dunstan, J Farrar, M Caws, ND Bang, NN Lan, TTH Chau, DJ Horne, NT Thuong, GE Thwaites, TR Hawn

American Journal of Respiratory Cell and Molecular Biology | AMER THORACIC SOC | Published : 2015

DOI: 10.1165/rcmb.2014-0114OC

Abstract

CD43, a surface glycoprotein, regulates Mycobacterium tuberculosis macrophage binding, replication, and proinflammatory cytokine induction in a murine model. We hypothesized that single-nucleotide polymorphisms (SNPs) in the CD43 gene region are associated with human tuberculosis (TB) susceptibility. We performed a case-population study in discovery (352 TB cases and 382 control subjects) and validation cohorts (339 TB cases and 376 control subjects). We examined whether 11 haplotype-tagging SNPs in the CD43 gene region were associated with tuberculous meningitis (TBM) and pulmonary TB (PTB) in Vietnam. Three SNPs from the CD43 gene region were associated with TB susceptibility with a genoty..

View full abstract

University of Melbourne Researchers

Sarah Dunstan Author

Grants

Awarded by National Institute of Allergy and Infectious Diseases

Funding Acknowledgements

This study was supported by a grant from the Firland Foundation (M.C.), by National Institute of Allergy and Infectious Diseases/National Institutes of Health grant K24AI089794 (T.R.H.), by the Burroughs Wellcome Foundation (T.R.H.), and by the Wellcome Trust of Great Britain (J.J.F.).