Journal article
Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis
LW Garratt, EN Sutanto, KM Ling, K Looi, T Iosifidis, KM Martinovich, NC Shaw, E Kicic-Starcevich, DA Knight, S Ranganathan, SM Stick, A Kicic
European Respiratory Journal | Published : 2015
Abstract
Neutrophil elastase is the most significant predictor of bronchiectasis in early-life cystic fibrosis; however, the causal link between neutrophil elastase and airway damage is not well understood. Matrix metalloproteinases (MMPs) play a crucial role in extracellular matrix modelling and are activated by neutrophil elastase. The aim of this study was to assess if MMP activation positively correlates with neutrophil elastase activity, disease severity and bronchiectasis in young children with cystic fibrosis. Total MMP-1, MMP-2, MMP-7, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-1 levels were measured in bronchoalveolar lavage fluid collected from young children with cystic..
View full abstractGrants
Awarded by Cystic Fibrosis Foundation Therapeutics
Awarded by National Health and Medical Research Council of Australia (NHMRC) (centre of research excellence)
Awarded by Cystic Fibrosis Australia
Funding Acknowledgements
Funding for the AREST CF programme was obtained from the Cystic Fibrosis Foundation Therapeutics (SLY04A0, STICK09A0), the National Health and Medical Research Council of Australia (NHMRC) (centre of research excellence #1000896) and project grant funding from the NHMRC and Cystic Fibrosis Australia (NHMRC 1043768). S.M. Stick is a NHMRC Practitioner Fellow. L.W. Garratt is funded by a PhD scholarship from the NHMRC and supplementary scholarships from the University of Western Australia and Cystic Fibrosis Western Australia. This research was presented in part at the Australasian Cystic Fibrosis Conference and the North American Cystic Fibrosis Conference with support from the University of Western Australia. Funding information for this article has been deposited with FundRef.