Journal article
Grey matter injury patterns in cerebral palsy: Associations between structural involvement on MRI and clinical outcomes
SM Reid, CD Dagia, MR Ditchfield, DS Reddihough
Developmental Medicine and Child Neurology | Published : 2015
DOI: 10.1111/dmcn.12800
Abstract
Aims: In a population cohort of children with grey matter injury (GMI) and cerebral palsy (CP), we aimed to describe and classify magnetic resonance imaging characteristics specific to GMI, and to identify key structure-function associations that serve as a basis for rating GMI in clinically relevant ways. Method: Symmetry, extent of cerebral injury, and pathological pattern for 54 children (37 males, 17 females) with CP and a predominant GMI pattern on chronic-phase magnetic resonance imaging were related to gross motor function, motor type and topography, epilepsy, intellectual disability, blindness, and deafness. Results: Relative to mild GMI where there was no pallidal abnormality, sever..
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Funding Acknowledgements
Assessment of MRI was funded by the William Henry and Vera Ellen Houston Memorial Trust Fund and the CP Alliance, and the study was supported by funds from the Ian Potter Foundation and the Lorenzo and Pamela Galli Trust. The Victorian Department of Health provided funding for the Victorian Cerebral Palsy Register. Infrastructure support was provided by the Victorian Government's Operational Infrastructure Support Program and the first author received salary support through an Early Career Fellowship (2014-2017) from the Australian National Health and Medical Research Council. None of the funders were involved in study design, data collection or analysis, manuscript preparation, or publication decisions. The authors have stated that they had no interests that might be perceived as posing a conflict or bias.