Journal article

Flatworms have lost the right open reading frame kinase 3 gene during evolution

Bert Breugelmans, Brendan RE Ansell, Neil D Young, Parisa Amani, Andreas J Stroehlein, Paul W Sternberg, Aaron R Jex, Peter R Boag, Andreas Hofmann, Robin B Gasser

Scientific Reports | NATURE PUBLISHING GROUP | Published : 2015

Abstract

All multicellular organisms studied to date have three right open reading frame kinase genes (designated riok-1, riok-2 and riok-3). Current evidence indicates that riok-1 and riok-2 have essential roles in ribosome biosynthesis, and that the riok-3 gene assists this process. In the present study, we conducted a detailed bioinformatic analysis of the riok gene family in 25 parasitic flatworms (platyhelminths) for which extensive genomic and transcriptomic data sets are available. We found that none of the flatworms studied have a riok-3 gene, which is unprecedented for multicellular organisms. We propose that, unlike in other eukaryotes, the loss of RIOK-3 from flatworms does not result in a..

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Grants

Awarded by Victorian Life Sciences Computation Initiative (VLSCI) on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government


Funding Acknowledgements

This project was funded by the National Health and Medical Research Council (NHMRC) of Australia and the Australian Research Council (ARC). This project was also supported by a Victorian Life Sciences Computation Initiative (VLSCI) grant number VR0007 on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government. Other support from the Australian Academy of Science, the Australian-American Fulbright Commission, Alexander von Humboldt Foundation, Melbourne Water Corporation (R.B.G.) is gratefully acknowledged, as is funding from the Howard Hughes Medical Institute (HHMI) and National Institutes of Health (NIH) (P.W.S.). N.D.Y. is an NHMRC Early Career Research (ECR) Fellow. We acknowledge the staff at WormBase (www.wormbase.org) and Wellcome Trust Sanger Institute (http://www.ebi.ac.uk/ena/data/view/PRJEB2709) for their support or provision of data. We acknowledge the use of the program I-TASSER - (c) 2013 The Regents of the University of Michigan.