Oxytocin and the modulation of pain experience: Implications for chronic pain management
Lincoln M Tracy, Nellie Georgiou-Karistianis, Stephen J Gibson, Melita J Giummarra
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2015
In an acute environment pain has potential protective benefits. However when pain becomes chronic this protective effect is lost and the pain becomes an encumbrance. Previously unheralded substances are being investigated in an attempt to alleviate the burden of living with chronic pain. Oxytocin, a neuropeptide hormone, is one prospective pharmacotherapeutic agent gaining popularity. Oxytocin has the potential to modulate the pain experience due to its ubiquitous involvement in central and peripheral psychological and physiological processes, and thus offers promise as a therapeutic agent. In this review, we discuss previous effective applications of oxytocin in pain-free clinical populatio..View full abstract
Awarded by Australian Research Council (ARC)
The conduct of this research project was funded by an Australian Research Council (ARC) Linkage Project Grant LP120200033, the Victorian Transport Accident Commission, and the School of Psychological Sciences, Monash University.MJG is supported by a NHMRC Early Career Fellowship (Clinical).