Journal article

Cardioprotection, attenuated systemic inflammation, and survival benefit of beta(1)-adrenoceptor blockade in severe sepsis in rats

Gareth L Ackland, Song T Yao, Alain Rudiger, Alex Dyson, Ray Stidwill, Dmitry Poputnikov, Mervyn Singer, Alexander V Gourine

Critical care medicine | LIPPINCOTT WILLIAMS & WILKINS | Published : 2010


OBJECTIVE: To explore the hypothesis that beta-1 adrenoreceptor blockade may be protective through the attenuation of sympathetic hyperactivity and catecholaminergic inflammatory effects on cardiac and hepatic function. DESIGN: Prospective, randomized, controlled study. SETTING: Animal laboratory in a university medical center. SUBJECTS: Male adult Wistar rats. INTERVENTIONS: Peripheral beta1-adrenoceptor blockade through daily intraperitoneal injection (metoprolol, 100 mg x kg(-1); atenolol, 6 mg x kg(-1)) or central nervous system beta1-adrenoceptor blockade (intracerebroventricular metoprolol, 25 microg) to achieve approximately 20% heart rate reduction in rats for 2 days before or after ..

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University of Melbourne Researchers