Journal article

14-3-3 proteins within the hypothalamic-neurohypophyseal system of the osmotically stressed rat: Transcriptomic and proteomic studies

SS Gouraud, ST Yao, KJ Heesom, JFR Paton, D Murphy

JOURNAL OF NEUROENDOCRINOLOGY | BLACKWELL PUBLISHING | Published : 2007

Abstract

The hypothalamic-neurohypophyseal system (HNS) mediates neuroendocrine responses to dehydration through the actions of the antidiuretic hormone vasopressin (VP) and the natriuetic peptide oxytocin (OT). VP and OT are synthesised as separate prepropeptide precursors in the cell bodies of magnocellular neurones in the hypothalamic supraoptic nucleus (SON) and paraventricular nucleus, the axons of which innervate the posterior pituitary gland (PP). Dehydration evokes a massive release of both peptides into the circulation, and this is accompanied by a function-related remodelling of the HNS. Microarray studies on mRNAs differentially expressed in the SON revealed that transcripts encoding the Y..

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