Journal article
The transcriptome of the medullary area postrema: The thirsty rat, the hungry rat and the hypertensive rat
CCT Hindmarch, M Fry, PM Smith, ST Yao, GGJ Hazell, SJ Lolait, JFR Paton, AV Ferguson, D Murphy
Experimental Physiology | WILEY-BLACKWELL | Published : 2011
Abstract
The area postrema (AP) is a sensory circumventricular organ characterized by extensive fenestrated vasculature and neurons which are capable of detecting circulating signals of osmotic, cardiovascular, immune and metabolic status. The AP can communicate these messages via efferent projections to brainstem and hypothalamic structures that are able to orchestrate an appropriate response. We have used microarrays to profile the transcriptome of the AP in the Sprague-Dawley (SD) and Wistar-Kyoto rat and present here a comprehensive catalogue of gene expression, focusing specifically on the population of ion channels, receptors and G protein-coupled receptors expressed in this sensory tissue; of ..
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Awarded by Medical Research Council
Funding Acknowledgements
This work was supported by British Heart Foundation, UK (D. M., J.F.R.P. and C. C. T. H.), Medical Research Council, UK (D. M.), Biotechnology and Biological Sciences Research Council, UK (D. M. and C. C. T. H.) and Canadian Institutes for Health Research (A. V. F.). J.F.R.P. was in receipt of a Royal Society Wolfson Research Merit Award.