5 alpha-Reduced Neurosteroids Sex-Dependently Reverse Central Prenatal Programming of Neuroendocrine Stress Responses in Rats

Grants

Funding Acknowledgements

This work was supported by the BBSRC, UK: BB/C518957/1 (P.J.B., J.A.R.), BB/J004332/1 (P.J.B.), BB/G006156/1 (M.G., S.T.Y., D.M); CAPES, Brazil (M.V.D.); British Heart Foundation (M.G., S.T.Y., D.M.); and The University of Malaya (HIR Award H-20001-E000086, D.M.). We thank Helen Cameron for technical assistance; undergraduate students, Robert Browning and Carly Schott assisted in some experiments;Megan Holmes (University of Edinburgh. UK) for providing the plasmids containing the rat CRY and ER-beta cDNA; Marcel Karperien and Dr Jakomijn Hoogendam (University of Leiden, The Netherlands) for providing the plasmid containing 5 alpha-reductase-1 cDNA; Trevor Penning (University of Pennsylvania, Philadelphia, PA) for providing the plasmid containing 3 alpha-hydroxysteroid dehydrogenase cDNA; and J. Ian Mason (University of Edinburgh, UK)for providing cDNA encoding 5 alpha-reductase-1.