Journal article

5 alpha-Reduced Neurosteroids Sex-Dependently Reverse Central Prenatal Programming of Neuroendocrine Stress Responses in Rats

Paula J Brunton, Marcio V Donadio, Song T Yao, Mike Greenwood, Jonathan R Seckl, David Murphy, John A Russell

The Journal of Neuroscience | SOC NEUROSCIENCE | Published : 2015

University of Melbourne Researchers

Grants

Awarded by BBSRC, UK


Awarded by University of Malaya (HIR)


Awarded by Biotechnology and Biological Sciences Research Council


Funding Acknowledgements

This work was supported by the BBSRC, UK: BB/C518957/1 (P.J.B., J.A.R.), BB/J004332/1 (P.J.B.), BB/G006156/1 (M.G., S.T.Y., D.M); CAPES, Brazil (M.V.D.); British Heart Foundation (M.G., S.T.Y., D.M.); and The University of Malaya (HIR Award H-20001-E000086, D.M.). We thank Helen Cameron for technical assistance; undergraduate students, Robert Browning and Carly Schott assisted in some experiments;Megan Holmes (University of Edinburgh. UK) for providing the plasmids containing the rat CRY and ER-beta cDNA; Marcel Karperien and Dr Jakomijn Hoogendam (University of Leiden, The Netherlands) for providing the plasmid containing 5 alpha-reductase-1 cDNA; Trevor Penning (University of Pennsylvania, Philadelphia, PA) for providing the plasmid containing 3 alpha-hydroxysteroid dehydrogenase cDNA; and J. Ian Mason (University of Edinburgh, UK)for providing cDNA encoding 5 alpha-reductase-1.