Journal article

Short-term effects of catheter-based renal denervation on cardiac sympathetic drive and cardiac baroreflex function in heart failure

Lindsea C Booth, Markus P Schlaich, Erika E Nishi, Song T Yao, Jianzhong Xu, Rohit Ramchandra, Gavin W Lambert, Clive N May

INTERNATIONAL JOURNAL OF CARDIOLOGY | ELSEVIER IRELAND LTD | Published : 2015

Abstract

OBJECTIVES: Sympathetic drive, especially to the heart, is elevated in heart failure and is strongly associated with poor outcome. The mechanisms causing the increased sympathetic drive to the heart remain poorly understood. Catheter-based renal denervation (RDN), which reduces blood pressure (BP) and sympathetic drive in hypertensive patients, is a potential treatment in heart failure. The aim of this study was to investigate the short-term effects of catheter-based RDN on BP, heart rate (HR) and cardiac sympathetic nerve activity (CSNA) and on baroreflex function in a conscious, large animal model of heart failure. METHODS: Adult Merino ewes were paced into heart failure (ejection fraction..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by NHMRC Early Career Fellowship


Awarded by Research Internships Abroad Fellowship of Sao Paulo Research Foundation


Awarded by NHMRC Research Fellowships


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia (NHMRC) (1012100) and the Victorian Government's Operational Infrastructure Support Program. L.C. Booth was the recipient of a NHMRC Early Career Fellowship, (1054619) E.E. Nishi was supported by a Research Internships Abroad Fellowship of Sao Paulo Research Foundation (12/05282-1), R. Ramchandra was supported by a NHMRC/National Heart Foundation co-funded Career Development Fellowship (1046372) and C.N. May (566819), M.P. Schlaich (1080404) and G.W. Lambert (1042492) were supported by NHMRC Research Fellowships.