Favourable response to ketogenic dietary therapies: undiagnosed glucose 1 transporter deficiency syndrome is only one factor

Grants

Funding Acknowledgements

This work was undertaken at University College London Hospitals NHS Foundation Trust and University College London, and a proportion of funding was received from the UK Department of Health's NIHR Biomedical Research Centres funding scheme. NES was supported by a UCL Impact Studentship in conjunction with The Katy Baggott Foundation and Epilepsy Society. JWS received research support from Epilepsy Society, the Dr Marvin Weil Epilepsy Research Fund, Eisai, GlaxoSmithKline, World Health Organization, EU FP7, and the US National Institutes of Health (NIH), and was consulted by and received fees for lectures from GSK, Eisai, and UCB Pharma. JHC received funds to the department for research into the ketogenic diet from Vitaflo. Honoraria for speaking were also made to the department on her behalf from Nuntranslated regionicia. JHC and IES have written a cookery book, 'Ketocooking', funds from the sale of which are donated to their respective departments. SMS received research support from the Epilepsy Society, The Wellcome Trust, The European Commission, Dravet Syndrome UK, Epilepsy Action, MRC, NIH, and The Katy Baggott Foundation, and received research support/fees from lectures from Eisai, GlaxoSmithKline, and UCB Pharma. The remaining authors have no conflicts of interest in relation to this work. We thank the patients and their families for participating in the research. We are grateful to the following clinicians and staff who assisted with recruitment and provided phenotypic details: C Eltze, M Sewell, C Fitzachary, and G Fitzsimmons (Great Ormond Street Hospital, London); R Williams, M-A Leung, T Randall, L Alford, A Tomalin, and E Hughes (Evelina London Children's Hospital, London); H Chan, C Ellerton, C Maritz, and R Lachmann (National Hospital for Neurology and Neurosurgery, London); B Concannon, S Philip, and V Hopkins (Birmingham Children's Hospital, Birmingham); P Fallon, O Stone, and N Dos Santos (St George's Hospital, London); V Aldridge, E Neal, T Stein, and A Desurkar (Matthew's Friends Clinics for Ketogenic Dietary Therapies, Surrey); H Champion, A Parker, and A Maw (Addenbrooke's Hospital, Cambridge); R Kneen and B Evans (Alder Hey Children's Hospital, Liverpool); M Dunlop and H Edwards (Bristol Royal Hospital for Sick Children, Bristol); J Bicknell-Royle (The Royal Children's Hospital, Melbourne, Australia); C Leu and A Tostevin (UCL Institute of Neurology, London). We also thank J White (UCL Genetics Institute) for discussions.