IL33 Is a Stomach Alarmin That Initiates a Skewed Th2 Response to Injury and Infection

JN Buzzelli; HV Chalinor; DI Pavlic; P Sutton; TR Menheniott; AS Giraud; LM Judd

Journal article

IL33 Is a Stomach Alarmin That Initiates a Skewed Th2 Response to Injury and Infection

JN Buzzelli, HV Chalinor, DI Pavlic, P Sutton, TR Menheniott, AS Giraud, LM Judd

Cellular and Molecular Gastroenterology and Hepatology | Published : 2015

DOI: 10.1016/j.jcmgh.2014.12.003

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Abstract

Background & Aims: Interleukin (IL)33 is a recently described alarmin that is highly expressed in the gastric mucosa and potently activates Th2 immunity. It may play a pivotal role during Helicobacter pylori infection. Here, we delineate the role of IL33 in the normal gastric mucosa and in response to gastropathy. Methods: IL33 expression was evaluated in mice and human biopsy specimens infected with H pylori and in mice after dosing with aspirin. IL33 expression was localized in the gastric mucosa using immunofluorescence. Mice were given 1 or 7 daily doses of recombinant IL33 (1 μg/dose), and the stomach and the spleen responses were quantified morphologically, by flow cytometry and using ..

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University of Melbourne Researchers

Phil Sutton Author

Louise M Judd Author

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study was supported by the Victorian Government's Operational Infrastructure Support Program and National Health and Medical Research Council Australia (APP1006688).