Journal article
Population pharmacokinetics, tolerability, and safety of dihydroartemisinin-piperaquine and sulfadoxine-pyrimethamine-piperaquine in pregnant and nonpregnant Papua New Guinean women
JM Benjamin, BR Moore, S Salman, M Page-Sharp, S Tawat, G Yadi, L Lorry, PM Siba, KT Batty, LJ Robinson, I Mueller, TME Davis
Antimicrobial Agents and Chemotherapy | Published : 2015
DOI: 10.1128/AAC.00326-15
Abstract
The tolerability, safety, and disposition of dihydroartemisinin (DHA) and piperaquine (PQ) were assessed in 32 pregnant (second/third trimester) and 33 nonpregnant Papua New Guinean women randomized to adult treatment courses of DHA-PQ (three daily doses) or sulfadoxine-pyrimethamine (SP)-PQ (three daily PQ doses, single dose of SP). All dose adminstrations were observed, and subjects fasted for 2 h postdose. Plasma PQ was assayed by using high-performance liquid chromatography, and DHA was assessed by using liquid chromatography-mass spectrometry. Compartmental pharmacokinetic models were developed using a population-based approach. Both regimens were well tolerated. There was an expected i..
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Funding Acknowledgements
This study was funded by the National Health and Medical Research Council (NHMRC) of Australia (grants 458555 and 634343). B.R.M. was supported by an NHMRC Early Career Fellowship (1036951), J.B. was supported by a Fogerty International Masters Scholarship, L.J.R. was supported by an NHMRC Early Career Fellowship (1016443), I.M. was supported by an NHMRC Senior Research Fellowship (1043345), and T.M.E.D. was supported by an NHMRC Practitioner Fellowship (572761).