Journal article
Confocal laser endomicroscopy to monitor the colonic mucosa of mice
L Mielke, A Preaudet, G Belz, T Putoczki
Journal of Immunological Methods | Published : 2015
Open access
Abstract
The gastrointestinal tract is a unique organ system that provides an epithelial barrier between our underlying immune system and luminal pathogens. Disruption of gastrointestinal homeostasis, as a result of impaired barrier function, is associated with numerous pathologies including inflammatory bowel disease and colorectal cancer. In parallel to the clinical development of endoscopy technologies to monitor and diagnose these pathologies in humans, advanced mouse colonoscopy techniques are being developed. When these technologies are coupled with model systems of human disease, which are essential to our understanding of the pathophysiology of gastrointestinal diseases, the requirement for e..
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Awarded by Worldwide Cancer Research
Funding Acknowledgements
We would like to thank CSL Ltd. (Melbourne, Australia) for supporting the purchase of the Karl Storz standard light endoscopy equipment, and TrendBio for providing access to the CellVizio confocal endoscopy system, The research in the laboratories of G.B. and T.P. is supported by The Victorian State Government Operational Infrastructure Support. The laboratory of T.P. is also funded by Worldwide Cancer Research (formally AICR). L.M. was funded by the National Health and Medical Research Council (APP1047903) and the Cancer Australia Priority-driven Collaborative Cancer Research Scheme, which was co-funded by the Cure Cancer Australia Foundation (APP1050241). This study was supported by an ANZ Trustees Medical Research and Technology Grant awarded to T.P.