Journal article

Mendelian randomization study of height and risk of colorectal cancer

Aaron P Thrift, Jian Gong, Ulrike Peters, Jenny Chang-Claude, Anja Rudolph, Martha L Slattery, Andrew T Chan, Tonu Esko, Andrew R Wood, Jian Yang, Sailaja Vedantam, Stefan Gustafsson, Tune H Pers, John A Baron, Stephane Bezieau, Sebastien Kuery, Shuji Ogino, Sonja I Berndt, Graham Casey, Robert W Haile Show all

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY | OXFORD UNIV PRESS | Published : 2015

Grants

Awarded by National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services


Awarded by National Institutes of Health (RFA)


Awarded by German Research Council (Deutsche Forschungsgemeinschaft)


Awarded by German Federal Ministry of Education and Research


Awarded by National Institutes of Health


Awarded by National Institutes of Health (NIH)


Awarded by Genes, Environment and Health Initiative (GEI)


Awarded by National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services


Awarded by Lundbeck Foundation


Funding Acknowledgements

This work is supported by grants to GECCO and CCFR, as well as by grants to the individual studies (as noted below). The funders of the study had no role in the design, analysis or interpretation of the data, or in writing or publication decisions related to this article.GECCO: National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services (U01 CA137088; R01 CA059045).CCFR: National Institutes of Health (RFA # CA-95-011) and through cooperative agreements with members of the Colon Cancer Family Registry and principal investigators. This genome-wide scan was supported by the National Cancer Institute, National Institutes of Health by U01 CA122839. The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centres in the CFRs, nor does mention of trade names, commercial products or organizations imply endorsement by the US Government or the CFR. The following Colon CFR centres contributed data to this manuscript and were supported by National Institutes of Health: Australasian Colorectal Cancer Family Registry (U01 CA097735), Ontario Registry for Studies of Familial Colorectal Cancer (U01 CA074783) and the Seattle Colorectal Cancer Family Registry (U01 CA074794).DACHS: German Research Council (Deutsche Forschungsgemeinschaft, BR 1704/6-1, BR 1704/6-3, BR 1704/6-4 and CH 117/1-1), and the German Federal Ministry of Education and Research (01KH0404 and 01ER0814).DALS: National Institutes of Health (R01 CA48998 to M.L.S).H.P.F.S. is supported by the National Institutes of Health (P01 CA 055075, UM1 CA167552, R01 137178, R01 CA 151993 and P50 CA 127003), N.H.S. by the National Institutes of Health (R01 CA137178, P01 CA 087969, R01 CA151993 and P50 CA 127003,) and P.H.S. by the National Institutes of Health (R01 CA042182).OFCCR: National Institutes of Health, through funding allocated to the Ontario Registry for Studies of Familial Colorectal Cancer (U01 CA074783); see CCFR section above. Additional funding toward genetic analyses of OFCCR includes the Ontario Research Fund, the Canadian Institutes of Health Research and the Ontario Institute for Cancer Research, through generous support from the Ontario Ministry of Research and Innovation.PLCO: Intramural Research Program of the Division of Cancer Epidemiology and Genetics and supported by contracts from the Division of Cancer Prevention, National Cancer Institute, NIH, DHHS. Additionally, a subset of control samples were genotyped as part of the Cancer Genetic Markers of Susceptibility (CGEMS) Prostate Cancer GWAS (Yeager M et al. Nat Genet 2007;39:645-49), Colon CGEMS pancreatic cancer scan (PanScan) (Amundadottir L et al. Nat Genet 2009;41:986-90 and Petersen GM et al. Nat Genet 2010;42:224-28), and the Lung Cancer and Smoking study. The prostate and PanScan study datasets were accessed with appropriate approval through the dbGaP online resource (http://cgems.cancer.gov/data/) accession numbers phs000207.v1.p1 and phs000206.v3.p2, respectively, and the lung datasets were accessed from the dbGaP website (http://www.ncbi.nlm.nih.gov/gap) through accession number phs000093.v2.p2. Funding for the Lung Cancer and Smoking study was provided by National Institutes of Health (NIH), Genes, Environment and Health Initiative (GEI) Z01 CP 010200, NIH U01 HG004446, and NIH GEI U01 HG 004438. For the lung study, the GENEVA Coordinating Center provided assistance with genotype cleaning and general study coordination, and the Johns Hopkins University Center for Inherited Disease Research conducted genotyping. PMH: National Institutes of Health (R01 CA076366 to P.A.N.). VITAL: National Institutes of Health (K05 CA154337).VITAL: National Institutes of Health (K05 CA154337). WHI: The WHI programme is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services through contracts HHSN 268201100046C, HHSN268201100001C, HHSN2682011000 02C, HHSN268201100003C, HHSN268201100004C and HHS N271201100004C.