Apnea after Awake Regional and General Anesthesia in Infants The General Anesthesia Compared to Spinal Anesthesia Study-Comparing Apnea and Neurodevelopmental Outcomes, a Randomized Controlled Trial
Andrew J Davidson, Neil S Morton, Sarah J Arnup, Jurgen C de Graaff, Nicola Disma, Davinia E Withington, Geoff Frawley, Rodney W Hunt, Pollyanna Hardy, Magda Khotcholava, Britta S von Ungern Sternberg, Niall Wilton, Pietro Tuo, Ida Salvo, Gillian Ormond, Robyn Stargatt, Bruno Guido Locatelli, Mary Ellen McCann
Anesthesiology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2015
BACKGROUND: Postoperative apnea is a complication in young infants. Awake regional anesthesia (RA) may reduce the risk; however, the evidence is weak. The General Anesthesia compared to Spinal anesthesia study is a randomized, controlled trial designed to assess the influence of general anesthesia (GA) on neurodevelopment. A secondary aim is to compare rates of apnea after anesthesia. METHODS: Infants aged 60 weeks or younger, postmenstrual age scheduled for inguinal herniorrhaphy, were randomized to RA or GA. Exclusion criteria included risk factors for adverse neurodevelopmental outcome and infants born less than 26 weeks gestation. The primary outcome of this analysis was any observed apn..View full abstract
Awarded by National Institute for Health Research
Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
All hospitals and centers were generously supported by anesthesiology departmental funding. In addition to this funding, specific grants received for this study are as follows: Australia and New Zealand: The Australian National Health & Medical Research Council, Canberra, Australian Capital Territory, Australia; Australian and New Zealand College of Anesthetists, Melbourne, Victoria, Australia; Murdoch Childrens Research Institute, Melbourne, Victoria, Australia. This study was supported by the Victorian Government's Operational Infrastructure Support Program in Melbourne, Victoria, Australia; Department of Anaesthesia and Pain Management, Royal Children's Hospital, Melbourne, Victoria, Australia; Department of Anaesthesia, Monash Medical Centre, Melbourne, Victoria, Australia; Department of Anaesthesia and Pain Management, Princess Margaret Hospital for Children, Perth, Western Australia, Australia; Department of Paediatric Anaesthesia, Women's Children's Hospital, Adelaide, South Australia, Australia and Department of Paediatric Anaesthesia and Operating Rooms, Starship Children's Hospital, Auckland, New Zealand. United States: National Institutes of Health, Bethesda, Maryland; Food and Drug Administration, Silver Spring, Maryland; Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts: Department of Anesthesia and Pain Medicine, Seattle Children's Hospital, Seattle, Washington; Department of Anesthesiology, Children's Hospital Colorado, Denver, Colorado; Department of Anesthesia, University of Iowa Hospital, Iowa City, Iowa; Department of Anesthesiology, Children's Medical Center Dallas, Dallas, Texas; Department of Pediatric Anesthesiology, Anne and Robert H. Lurie Children's Memorial Hospital, Chicago, Illinois; Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire; Department of Pediatric Anesthesia, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; and Department of Anesthesia and Pediatrics, The University of Vermont/Fletcher Allen Health Care, Burlington, Vermont. Italy: Italian Ministry of Health, Rome, Italy; Department of Anesthesia, Istituto Giannina Gaslini, Genoa, Italy; Department of Anesthesiology and Paediatric Intensive Care, Ospedale Vittore Buzzi, Milan, Italy; and Department of Anaesthesia, Ospedale Papa Giovanni XXIII, Bergamo, Italy. The Netherlands: Fonds NutsOhra, Amsterdam, The Netherlands; Department of Anesthesiology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands; and Department of Anesthesiology, University Medical Center Groningen, Groningen, The Netherlands. Canada: Canadian Institute of Health Research, Ottawa, Ontario, Canada; Canadian Anesthesiologists' Society, Toronto, Ontario, Canada; Pfizer Canada, Inc., Kirkland, Quebec, Canada; Department of Anesthesia, Montreal Children's Hospital, Montreal, Quebec, Canada; and Departement d'Anesthesie, CHU Sainte-Justine, Montreal, Quebec, Canada. United Kingdom: Health Technologies Assessment-National Institute for Health Research United Kingdom, Southampton, United Kingdom.Anesthesiology Departmental Funding: Department of Anaesthesia, Royal Hospital for Sick Children, Glasgow, United Kingdom; Department of Anaesthesia, Birmingham Children's Hospital, Birmingham, United Kingdom; Anaesthetic Department, Sheffield Children's Hospital, Sheffield, United Kingdom; Department of Paediatric Anaesthesia, Bristol Royal Hospital for Children, Bristol, United Kingdom; Department of Anaesthetics, Royal Belfast Hospital for Sick Children, Belfast, United Kingdom; and Department of Anaesthesia, Pain Relief and Sedation, Alder Hey Childrens' NHS Foundation Trust, Liverpool, United Kingdom.