Comparing the effects of 17 beta-oestradiol and the selective oestrogen receptor modulators, raloxifene and tamoxifen, on prepulse inhibition in female rats
Andrea Gogos, Maarten van den Buuse
SCHIZOPHRENIA RESEARCH | ELSEVIER SCIENCE BV | Published : 2015
BACKGROUND: Evidence suggests that oestrogen plays a protective role against the development and severity of schizophrenia. However, while oestrogen may be beneficial as a treatment in schizophrenia, its chronic use is associated with side-effects. Selective oestrogen receptor modulators (SERMs) may provide an alternative, however little is known about the mechanism underlying their effects in schizophrenia. METHODS: We investigated the effect of raloxifene and tamoxifen on dopaminergic-induced disruptions of prepulse inhibition (PPI). PPI measures sensorimotor gating and PPI disruptions are considered an endophenotype for schizophrenia. Adult female Sprague-Dawley rats were either intact, o..View full abstract
The funding sources provided salaries to the authors. The ARC DECRA also provided the funds for carrying out the project.