Journal article

Predictors of disability worsening in clinically isolated syndrome

Vilija G Jokubaitis, Tim Spelman, Tomas Kalincik, Guillermo Izquierdo, Francois Grand'Maison, Pierre Duquette, Marc Girard, Alessandra Lugaresi, Pierre Grammond, Raymond Hupperts, Jose Cabrera-Gomez, Celia Oreja-Guevara, Cavit Boz, Giorgio Giuliani, Ricardo Fernandez-Bolanos, Gerardo Iuliano, Jeannette Lechner-Scott, Freek Verheul, Vincent van Pesch, Tatjana Petkovska-Boskova Show all

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | WILEY-BLACKWELL | Published : 2015

Abstract

OBJECTIVE: To assess demographic, clinical, magnetic resonance imaging, and treatment exposure predictors of time to 3 or 12-month confirmed disability worsening in clinically isolated syndrome (CIS) and early multiple sclerosis (MS). METHODS: We utilized the MSBase Incident Study (MSBasis), a prospective cohort study of outcome after CIS. Predictors of time to first 3 and 12-month confirmed expanded disability status scale worsening were analyzed using Cox proportional hazards regression. RESULTS: About 1989 patients were analyzed, the largest seen-from-onset cohort reported to-date. A total of 391 patients had a first 3-month confirmed disability worsening event, of which 307 were sustaine..

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