Journal article
Neuregulin 1 expression and electrophysiological abnormalities in the Neuregulin 1 transmembrane domain heterozygous mutant mouse
LE Long, P Anderson, E Frank, A Shaw, S Liu, XF Huang, D Pinault, T Karl, TJ O'Brien, CS Weickert, NC Jones
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2015
Open access
Abstract
Background: The Neuregulin 1 transmembrane domain heterozygous mutant (Nrg1 TM HET) mouse is used to investigate the role of Nrg1 in brain function and schizophrenia-like behavioural phenotypes. However, the molecular alterations in brain Nrg1 expression that underpin the behavioural observations have been assumed, but not directly determined. Here we comprehensively characterise mRNA Nrg1 transcripts throughout development of the Nrg1 TM HET mouse. In addition, we investigate the regulation of high-frequency (gamma) electrophysiological oscillations in this mutant mouse to associate molecular changes in Nrg1 with a schizophrenia-relevant neurophysiological profile. Methods: Using exonic pro..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the Schizophrenia Research Institute (utilising infrastructure funding from the NSW Ministry of Health and the Macquarie Group Foundation), the University of New South Wales and Neuroscience Research Australia. PA is supported by an Australian Rotary Health Ian Scott PhD Scholarship. TK is supported by the Motor Neuron Disease Research Institute of Australia (Mick Rodger Benalla MND Research Grant) and a career development fellowship (1045643) and a project grant (1003886) from the NHMRC. CSW is supported by a Senior Research Fellowship (1021970) from the National Health and Medical Research Council (NHMRC). NCJ is supported by a Future Fellowship (130100100) from the Australian Research Council (ARC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.