Journal article

Broadband Onset Inhibition Can Suppress Spectral Splatter in the Auditory Brainstem

Martin J Spencer, David AX Nayagam, Janine C Clarey, Antonio G Paolini, Hamish Meffin, Anthony N Burkitt, David B Grayden

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2015

Abstract

In vivo intracellular responses to auditory stimuli revealed that, in a particular population of cells of the ventral nucleus of the lateral lemniscus (VNLL) of rats, fast inhibition occurred before the first action potential. These experimental data were used to constrain a leaky integrate-and-fire (LIF) model of the neurons in this circuit. The post-synaptic potentials of the VNLL cell population were characterized using a method of triggered averaging. Analysis suggested that these inhibited VNLL cells produce action potentials in response to a particular magnitude of the rate of change of their membrane potential. The LIF model was modified to incorporate the VNLL cells' distinctive acti..

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Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by Australian Research Council


Funding Acknowledgements

Martin Spencer acknowledges postgraduate scholarships from the National Health and Medical Research Council of Australia (NHMRC - 567164 - www.nhmrc.gov.au/) and National Information and Communication Technology Australia (NICTA - www.nicta.com.au/). The work was supported by the Australian Research Council (DP1094830 - www.arc.gov.au/). NICTA is funded by the Australian Government as represented by the Department of Broadband, Communications and the Digital Economy (www.communications.gov.au/) and the Australian Research Council through the ICT Centre of Excellence program. The Bionics Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program (http://www.business.vic.gov.au/grants-and-assistance/programs/medicalresearch-operational-infrastructure-program). We acknowledge the late Dame Elisabeth Murdoch for funding the original in vivo research on which the present manuscript is based. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.