Journal article
Oxidized low-density lipoprotein alters endothelial progenitor cell populations
Y Cui, CA Narasimhulu, L Liu, X Li, Y Xiao, J Zhang, X Xie, H Hao, JZ Liu, G He, PJ Cowan, L Cui, H Zhu, S Parthasarathy, Z Liu
Frontiers in Bioscience Landmark | FRONTIERS IN BIOSCIENCE INC | Published : 2015
DOI: 10.2741/4351
Abstract
Oxidized low-density lipoprotein (ox-LDL) is critical to atherosclerosis in hyperlipidemia. Bone marrow (BM)-derived endothelial progenitor cells (EPCs) are important in preventing atherosclerosis, however these cells are significantly decreased in number in hyperlipidemia. This study aimed to determine whether ox-LDL and hyperlipidemia exert similar effects on EPC populations, and to investigate the involvement of reactive oxygen species (ROS). ROS production in BM and blood was significantly increased in male C57BL/6 mice treated with intravenous ox-LDL, and in hyperlipidemic LDL receptor knockout mice fed with a 4-month high-fat diet. ROS formation was effectively blocked by overexpressio..
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Awarded by National Heart, Lung, and Blood Institute
Funding Acknowledgements
This work was supported by a US NIH grant to ZL (Grant number NIH R01 HL094650).